404 Media

2025-08-27 15:00:09

Scientists Make Breakthrough in Solving the Mystery of Life’s Origin

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Scientists have made a major breakthrough in the mystery of how life first emerged on Earth by demonstrating how two essential biological ingredients could have spontaneously joined together on our planet some four billion years ago.

All life on Earth contains ribonucleic acid (RNA), a special molecule that helps build proteins from simpler amino acids. To kickstart this fundamental biological process, RNA and amino acids had to become attached at some point. But this key step, known as RNA aminoacylation, has never been experimentally observed in early Earth-like conditions despite the best efforts of many researchers over the decades.

Now, a team has achieved this milestone in the quest to unravel life’s origins. As they report in a study published on Wednesday in Nature, the researchers were able to link amino acids to RNA in water at a neutral pH with the aid of energetic chemical compounds called thioesters. The work revealed that two contrasting origin stories for life on Earth, known as “RNA world” and “thioester world,” may both be right.

“It unites two theories for the origin of life, which are totally separate,” said Matthew Powner, a professor of organic chemistry at University College London and an author of the study, in a call with 404 Media. “These were opposed theories—either you have thioesters or you have RNA.”

“What we found, which is kind of cool, is that if you put them both together, they're more than the sum of their parts,” he continued. “Both aspects—RNA world and thioester world—might be right and they’re not mutually exclusive. They can both work together to provide different aspects of things that are essential to building a cell.”

In the RNA world theory, which dates back to the 1960s, self-replicating RNA molecules served as the initial catalysts for life. The thioester world theory, which gained traction in the 1990s, posits that life first emerged from metabolic processes spurred on by energetic thioesters. Now, Powner said, the team has found a “missing link” between the two.

Powner and his colleagues didn’t initially set out to merge the two ideas. The breakthrough came almost as a surprise after the team synthesized pantetheine, a component of thioesters, in simulated conditions resembling early Earth. The team discovered that if amino acids are linked to pantetheine, they naturally attach themselves to RNA at molecular sites that are consistent with what is seen in living things. This act of RNA aminoacylation could eventually enable the complex protein synthesis all organisms now depend on to live.

Pantetheine “is totally universal,” Powner explained. “Every organism on Earth, every genome sequence, needs this molecule for some reason or other. You can't take it out of life and fully understand life.”

“That whole program of looking at pantetheine, and then finding this remarkable chemistry that pantetheine does, was all originally designed to just be a side study,” he added. “It was serendipity in the sense that we didn't expect it, but in a scientific way that we knew it would probably be interesting and we'd probably find uses for it. It’s just the uses we found were not necessarily the ones we expected.”

The researchers suggest that early instances of RNA aminoacylation on Earth would most likely have occurred in lakes and other small bodies of water, where nutrients could accumulate in concentrations that could up the odds of amino acids attaching to RNA.

“It's very difficult to envisage any origins of life chemistry in something as large as an ocean body because it's just too dilute for chemistry,” Powner said. For that reason, they suggest future studies of so-called “soda lakes” in polar environments that are rich in nutrients, like phosphate, and could serve as models for the first nurseries of life on Earth.

The finding could even have implications for extraterrestrial life. If life on Earth first emerged due, in part, to this newly identified process, it’s possible that similar prebiotic reactions can be set in motion elsewhere in the universe. Complex molecules like pantetheine and RNA have never been found off-Earth (yet), but amino acids are present in many extraterrestrial environments. This suggests that the ingredients of life are abundant in the universe, even if the conditions required to spark it are far more rare.

While the study sheds new light on the origin of life, there are plenty of other steps that must be reconstructed to understand how inorganic matter somehow found a way to self-replicate and start evolving, moving around, and in our case as humans, conducting experiments to figure out how it all got started.

“We get so focused on the details of what we're trying to do that we don't often step back and think, ‘Oh, wow, this is really important and existential for us,’” Powner concluded.

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Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water - Nature

Aminoacyl-thiols reacting selectively with RNA diols over amine nucleophiles and demonstration of chemically controlled formation of peptidyl-RNA in water at neutral pH suggest an important role for thiol cofactors before the evolution of enzymes.

^Nature

404 Media

2025-08-27 20:22:43

Developer Unlocks Newly Enshittified Echelon Exercise Bikes But Can't Legally Release His Software

An app developer has jailbroken Echelon exercise bikes to restore functionality that the company put behind a paywall last month, but copyright laws prevent him from being allowed to legally release it.

Last month, Peloton competitor Echelon pushed a firmware update to its exercise equipment that forces its machines to connect to the company’s servers in order to work properly. Echelon was popular in part because it was possible to connect Echelon bikes, treadmills, and rowing machines to free or cheap third-party apps and collect information like pedaling power, distance traveled, and other basic functionality that one might want from a piece of exercise equipment. With the new firmware update, the machines work only with constant internet access and getting anything beyond extremely basic functionality requires an Echelon subscription, which can cost hundreds of dollars a year.

In the immediate aftermath of this decision, right to repair advocate and popular YouTuber Louis Rossmann announced a $20,000 bounty through his new organization, the Fulu Foundation, to anyone who was able to jailbreak and unlock Echelon equipment: “I’m tired of this shit,” Rossmann said in a video announcing the bounty. “Fulu Foundation is going to offer a bounty of $20,000 to the first person who repairs this issue. And I call this a repair because I believe that the firmware update that they pushed out breaks your bike.”
youtube.com/embed/2zayHD4kfcA?…
App engineer Ricky Witherspoon, who makes an app called SyncSpin that used to work with Echelon bikes, told 404 Media that he successfully restored offline functionality to Echelon equipment and won the Fulu Foundation bounty. But he and the foundation said that he cannot open source or release it because doing so would run afoul of Section 1201 of the Digital Millennium Copyright Act, the wide-ranging copyright law that in part governs reverse engineering. There are various exemptions to Section 1201, but most of them allow for jailbreaks like the one Witherspoon developed to only be used for personal use.

“It’s like picking a lock, and it’s a lock that I own in my own house. I bought this bike, it was unlocked when I bought it, why can’t I distribute this to people who don’t have the technical expertise I do?” Witherspoon told 404 Media. “It would be one thing if they sold the bike with this limitation up front, but that’s not the case. They reached into my house and forced this update on me without users knowing. It’s just really unfortunate.”

Kevin O’Reilly, who works with Rossmann on the Fulu Foundation and is a longtime right to repair advocate, told 404 Media that the foundation has paid out Witherspoon’s bounty.

“A lot of people chose Echelon’s ecosystem because they didn’t want to be locked into using Echelon’s app. There was this third-party ecosystem. That was their draw to the bike in the first place,” O’Reilly said. “But now, if the manufacturer can come in and push a firmware update that requires you to pay for subscription features that you used to have on a device you bought in the first place, well, you don’t really own it.”

“I think this is part of the broader trend of enshittification, right?,” O’Reilly added. “Consumers are feeling this across the board, whether it’s devices we bought or apps we use—it’s clear that what we thought we were getting is not continuing to be provided to us.”

Witherspoon says that, basically, Echelon added an authentication layer to its products, where the piece of exercise equipment checks to make sure that it is online and connected to Echelon’s servers before it begins to send information from the equipment to an app over Bluetooth. “There’s this precondition where the bike offers an authentication challenge before it will stream those values. It is like a true digital lock,” he said. “Once you give the bike the key, it works like it used to. I had to insert this [authentication layer] into the code of my app, and now it works.”

Witherspoon has now essentially restored functionality that he used to have to his own bike, which he said he bought in the first place because of its ability to work offline and its ability to connect to third-party apps. But others will only be able to do it if they design similar software, or if they never update the bike’s firmware. Witherspoon said that he made the old version of his SyncSpin app free and has plastered it with a warning urging people to not open the official Echelon app, because it will update the firmware on their equipment and will break functionality. Roberto Viola, the developer of a popular third-party exercise app called QZ, wrote extensively about how Echelon has broken his popular app: “Without warning, Echelon pushed a firmware update. It didn’t just upgrade features—it locked down the entire device. From now on, bikes, treadmills, and rowers must connect to Echelon’s servers just to boot,” he wrote. “No internet? No workout. Even basic offline usage is impossible. If Echelon ever shuts down its servers (it happens!), your expensive bike becomes just metal. If you care about device freedom, offline workouts, or open compatibility: Avoid all firmware updates. Disable automatic updates. Stay alert.”

Witherspoon told me that he is willing to talk to other developers about how he did this, but that he is not willing to release the jailbreak on his own: “I don’t feel like going down a legal rabbit hole, so for now it’s just about spreading awareness that this is possible, and that there’s another example of egregious behavior from a company like this […] if one day releasing this was made legal, I would absolutely open source this. I can legally talk about how I did this to a certain degree, and if someone else wants to do this, they can open source it if they want to.”

Echelon did not immediately respond to a request for comment.

How I Built QZ—and How Echelon Is Now Breaking It - Roberto Viola

By Roberto Viola, creator of QZ On September 10, 2020, I began building QZ (qdomyos-zwift), an app born from a simple idea: open up closed fitness hardware and make it work with the platforms people actually love—Zwift, Peloton, Kinomap, and more.

^{cagnulein (Roberto Viola)}